Ontology highlight
ABSTRACT:
SUBMITTER: Cabeza-Cabrerizo M
PROVIDER: S-EPMC6420147 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Cabeza-Cabrerizo Mar M van Blijswijk Janneke J Wienert Stephan S Heim Daniel D Jenkins Robert P RP Chakravarty Probir P Rogers Neil N Frederico Bruno B Acton Sophie S Beerling Evelyne E van Rheenen Jacco J Clevers Hans H Schraml Barbara U BU Bajénoff Marc M Gerner Michael M Germain Ronald N RN Sahai Erik E Klauschen Frederick F Reis e Sousa Caetano C
Science immunology 20190301 33
Conventional dendritic cells (cDCs) are found in all tissues and play a key role in immune surveillance. They comprise two major subsets, cDC1 and cDC2, both derived from circulating precursors of cDCs (pre-cDCs), which exited the bone marrow. We show that, in the steady-state mouse, pre-cDCs entering tissues proliferate to give rise to differentiated cDCs, which themselves have residual proliferative capacity. We use multicolor fate mapping of cDC progenitors to show that this results in clones ...[more]