Corneal nerve and endothelial cell damage in patients with transient ischemic attack and minor ischemic stroke.
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ABSTRACT: Objective
To determine if corneal confocal microscopy can identify corneal nerve and endothelial cell abnormalities and may be useful in the prognostication of patients with transient ischemic attack [1] or minor ischemic stroke (IS).Methods
Thirty-six patients admitted with TIA (n = 14) or minor IS (n = 22) underwent transcranial Doppler evaluation and corneal confocal microscopy and were compared with 18 healthy controls.Results
Corneal nerve fiber density (P = 0.002), branch density (P = 0.004) and fiber length (P = 0.004) were significantly lower in patients with TIA or minor IS compared to controls, with no difference between patients with TIA and minor IS. Endothelial cell density (P = 0.003) was lower and endothelial cell area (P = 0.003) and perimeter (P = 0.006) were significantly higher in patients with TIA or minor IS compared to controls, with no difference between patients with TIA and minor IS. There were no differences in corneal nerve or endothelial cell morphology between patients with and without abnormal cerebrovascular reactivity. HbA1c was independently associated with CNFL, and endothelial cell polymegathism and pleomorphism were associated with both HbA1c and total cholesterol.Conclusion
Corneal confocal microscopy identifies corneal nerve fiber loss and endothelial cell abnormalities in patients with TIA and minor IS and independent associations with HbA1c and cholesterol.
SUBMITTER: Gad H
PROVIDER: S-EPMC6420175 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Corneal nerve and endothelial cell damage in patients with transient ischemic attack and minor ischemic stroke.
Gad Hoda H Khan Adnan A Akhtar Naveed N Kamran Saadat S El-Sotouhy Ahmed A Dargham Soha R SR Petropoulos Ioannis N IN Ponirakis Georgios G Shuaib Ashfaq A Streletz Leopold J LJ Malik Rayaz A RA
PloS one 20190315 3
<h4>Objective</h4>To determine if corneal confocal microscopy can identify corneal nerve and endothelial cell abnormalities and may be useful in the prognostication of patients with transient ischemic attack [1] or minor ischemic stroke (IS).<h4>Methods</h4>Thirty-six patients admitted with TIA (n = 14) or minor IS (n = 22) underwent transcranial Doppler evaluation and corneal confocal microscopy and were compared with 18 healthy controls.<h4>Results</h4>Corneal nerve fiber density (P = 0.002), ...[more]
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