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ABSTRACT: Background
Generic versions of a drug can vary in appearance, which can impact adherence.Objective
To assess the preferences, perceptions, and responses of patients who experienced a change in the appearance of a generic medication.Design
Cross-sectional survey of patients from a large commercial health plan.Participants
Adults receiving generic versions of lisinopril, fluoxetine, lamotrigine, or simvastatin who experienced a change in the color or shape of their pills between March 2014 and November 2015.Main measures
Likert-scale responses to questions concerning perceptions of generic drug safety and effectiveness, reliance on and preferences for pill appearance, and responses to pill appearance changes. Multivariable logistic regression-modeled predictors of seeking advice and adjusting use following a pill appearance change.Key results
Of 814 respondents (response rate?=?41%), 72% relied on pill appearance to ensure they took the correct medication. A similar percentage wanted their pills to remain the same color (72%), shape (71%), and size (75%) upon refill, but 58% would not have paid a $1 premium on a $5 co-pay to ensure such consistency. Most respondents (86%) wanted their pharmacists to notify them about pill appearance changes, but only 37% recalled such notification; 21% thought they received the wrong medication, and 8% adjusted medication use. Younger respondents (18-33 vs. 50-57 years) were more likely to seek advice (odds ratio [OR]?=?1.91; 95% confidence interval [CI],1.02-3.59), and respondents with lower household income (?$100,000) were more likely to adjust medication use (OR?=?3.40; 95% CI,1.09-10.67).Conclusions
Requiring uniform pill appearance may help increase adherence but presents challenges. Standardized pharmacy notification and education policies may be a more feasible short-term solution.
SUBMITTER: Sarpatwari A
PROVIDER: S-EPMC6420535 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Sarpatwari Ameet A Gagne Joshua J JJ Lu Zhigang Z Campbell Eric G EG Carman Wendy J WJ Enger Cheryl L CL Dutcher Sarah K SK Jiang Wenlei W Kesselheim Aaron S AS
Journal of general internal medicine 20190110 3
<h4>Background</h4>Generic versions of a drug can vary in appearance, which can impact adherence.<h4>Objective</h4>To assess the preferences, perceptions, and responses of patients who experienced a change in the appearance of a generic medication.<h4>Design</h4>Cross-sectional survey of patients from a large commercial health plan.<h4>Participants</h4>Adults receiving generic versions of lisinopril, fluoxetine, lamotrigine, or simvastatin who experienced a change in the color or shape of their ...[more]