Pathogenesis and biomarkers of natural killer T cell lymphoma (NKTL).
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ABSTRACT:
SUBMITTER: Somasundaram N
PROVIDER: S-EPMC6420729 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Pathogenesis and biomarkers of natural killer T cell lymphoma (NKTL).
Somasundaram Nagavalli N Lim Jing Quan JQ Ong Choon Kiat CK Lim Soon Thye ST
Journal of hematology & oncology 20190315 1
Natural killer T cell lymphoma (NKTL) is an aggressive disease with very poor treatment outcomes in the advanced stages. With chemotherapy, initial response rates to treatment are high but responses are short lived. A better understanding of the complex molecular pathogenesis of this disease is essential in order to design and develop better therapeutics with improved efficacy. This review aims to summarise the key pathogenic mechanisms in NKTL which may have significant prognostic and therapeut ...[more]
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