Ontology highlight
ABSTRACT:
SUBMITTER: Knighton LE
PROVIDER: S-EPMC6421096 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Knighton Laura E LE Delgado Lena E LE Truman Andrew W AW
Current genetics 20181205 2
The molecular chaperones Hsp70 and Hsp90 bind and fold a significant proportion of the proteome. They are responsible for the activity and stability of many disease-related proteins including those in cancer. Substantial effort has been devoted to developing a range of chaperone inhibitors for clinical use. Recent studies have identified the oncogenic ribonucleotide reductase (RNR) complex as an interactor of chaperones. While several generations of RNR inhibitor have been developed for use in c ...[more]