Ontology highlight
ABSTRACT:
SUBMITTER: Zukowski A
PROVIDER: S-EPMC6421107 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Zukowski Alexis A Phillips Juliana J Park Soyeon S Wu Ronghu R Gygi Steven P SP Johnson Aaron M AM
Current genetics 20181012 2
Heterochromatin domains are stably repressed chromatin structures composed of a core assembly of silencing proteins that condense adjacent nucleosomes. The minimal heterochromatin structure can serve as a platform for recruitment of complementary regulatory factors. We find that a reconstituted budding yeast heterochromatin domain can act as a platform to recruit multiple factors that play a role in regulating heterochromatin function. We uncover the direct interaction between the SIR heterochro ...[more]