Ontology highlight
ABSTRACT:
SUBMITTER: Mossu A
PROVIDER: S-EPMC6421249 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Mossu Adrien A Rosito Maria M Khire Tejas T Li Chung Hung H Nishihara Hideaki H Gruber Isabelle I Luke Emma E Dehouck Lucie L Sallusto Federica F Gosselet Fabien F McGrath James L JL Engelhardt Britta B
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20181219 3
Here we report on the development of a breakthrough microfluidic human in vitro cerebrovascular barrier (CVB) model featuring stem cell-derived brain-like endothelial cells (BLECs) and nanoporous silicon nitride (NPN) membranes (µSiM-CVB). The nanoscale thinness of NPN membranes combined with their high permeability and optical transparency makes them an ideal scaffold for the assembly of an in vitro microfluidic model of the blood-brain barrier (BBB) featuring cellular elements of the neurovasc ...[more]