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Sex differences in estimated brain metabolism in relation to body growth through adolescence.

ABSTRACT: The human brain consumes a disproportionate amount of the body's overall metabolic resources, and evidence suggests that brain and body may compete for substrate during development. Using perfusion MRI from a large cross-sectional cohort, we examined developmental changes of MRI-derived estimates of brain metabolism, in relation to weight change. Nonlinear models demonstrated that, in childhood, changes in body weight were inversely related to developmental age-related changes in brain metabolism. This inverse relationship persisted through early adolescence, after which body and brain metabolism began to decline. Females achieved maximum body growth approximately two years earlier than males, with a correspondingly earlier stabilization of brain metabolism to adult levels. These findings confirm prior findings with positron emission tomography performed in a much smaller cohort, demonstrate that relative brain metabolism can be inferred from noninvasive MRI data, and extend observations on the associations between body growth and brain metabolism to sex differences through adolescence.

SUBMITTER: Vandekar SN

PROVIDER: S-EPMC6421255 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Sex differences in estimated brain metabolism in relation to body growth through adolescence.

Vandekar Simon N SN Shou Haochang H Satterthwaite Theodore D TD Shinohara Russell T RT Merikangas Alison K AK Roalf David R DR Ruparel Kosha K Rosen Adon A Gennatas Efstathios D ED Elliott Mark A MA Davatzikos Christos C Gur Ruben C RC Gur Raquel E RE Detre John A JA

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20171026 3

The human brain consumes a disproportionate amount of the body's overall metabolic resources, and evidence suggests that brain and body may compete for substrate during development. Using perfusion MRI from a large cross-sectional cohort, we examined developmental changes of MRI-derived estimates of brain metabolism, in relation to weight change. Nonlinear models demonstrated that, in childhood, changes in body weight were inversely related to developmental age-related changes in brain metabolis ...[more]

PMID: 29072856

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Project description:Background/objectivesThe brain has a central role in regulating ingestive behavior in obesity. Analogous to addiction behaviors, an imbalance in the processing of rewarding and salient stimuli results in maladaptive eating behaviors that override homeostatic needs. We performed network analysis based on graph theory to examine the association between body mass index (BMI) and network measures of integrity, information flow and global communication (centrality) in reward, salience and sensorimotor regions and to identify sex-related differences in these parameters.Subjects/methodsStructural and diffusion tensor imaging were obtained in a sample of 124 individuals (61 males and 63 females). Graph theory was applied to calculate anatomical network properties (centrality) for regions of the reward, salience and sensorimotor networks. General linear models with linear contrasts were performed to test for BMI and sex-related differences in measures of centrality, while controlling for age.ResultsIn both males and females, individuals with high BMI (obese and overweight) had greater anatomical centrality (greater connectivity) of reward (putamen) and salience (anterior insula) network regions. Sex differences were observed both in individuals with normal and elevated BMI. In individuals with high BMI, females compared to males showed greater centrality in reward (amygdala, hippocampus and nucleus accumbens) and salience (anterior mid-cingulate cortex) regions, while males compared to females had greater centrality in reward (putamen) and sensorimotor (posterior insula) regions.ConclusionsIn individuals with increased BMI, reward, salience and sensorimotor network regions are susceptible to topological restructuring in a sex-related manner. These findings highlight the influence of these regions on integrative processing of food-related stimuli and increased ingestive behavior in obesity, or in the influence of hedonic ingestion on brain topological restructuring. The observed sex differences emphasize the importance of considering sex differences in obesity pathophysiology.

Dataset Information

Sex differences in estimated brain metabolism in relation to body growth through adolescence.

Publications

Sex differences in estimated brain metabolism in relation to body growth through adolescence.

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