Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis.
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ABSTRACT:
SUBMITTER: Jacobs RT
PROVIDER: S-EPMC6421521 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
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Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis.
Jacobs Robert T RT Lunde Christopher S CS Freund Yvonne R YR Hernandez Vincent V Li Xianfeng X Xia Yi Y Carter David S DS Berry Pamela W PW Halladay Jason J Rock Fernando F Stefanakis Rianna R Easom Eric E Plattner Jacob J JJ Ford Louise L Johnston Kelly L KL Cook Darren A N DAN Clare Rachel R Cassidy Andrew A Myhill Laura L Tyrer Hayley H Gamble Joanne J Guimaraes Ana F AF Steven Andrew A Lenz Franziska F Ehrens Alexandra A Frohberger Stefan J SJ Koschel Marianne M Hoerauf Achim A Hübner Marc P MP McNamara Case W CW Bakowski Malina A MA Turner Joseph D JD Taylor Mark J MJ Ward Stephen A SA
Journal of medicinal chemistry 20190226 5
A series of pleuromutilins modified by introduction of a boron-containing heterocycle on C(14) of the polycyclic core are described. These analogs were found to be potent anti- Wolbachia antibiotics and, as such, may be useful in the treatment of filarial infections caused by Onchocerca volvulus, resulting in Onchocerciasis or river blindness, or Wuchereria bancrofti and Brugia malayi and related parasitic nematodes resulting in lymphatic filariasis. These two important neglected tropical diseas ...[more]
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