Ontology highlight
ABSTRACT:
SUBMITTER: Jacobs RT
PROVIDER: S-EPMC6421521 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20190226 5
A series of pleuromutilins modified by introduction of a boron-containing heterocycle on C(14) of the polycyclic core are described. These analogs were found to be potent anti- Wolbachia antibiotics and, as such, may be useful in the treatment of filarial infections caused by Onchocerca volvulus, resulting in Onchocerciasis or river blindness, or Wuchereria bancrofti and Brugia malayi and related parasitic nematodes resulting in lymphatic filariasis. These two important neglected tropical diseas ...[more]