Ontology highlight
ABSTRACT:
SUBMITTER: Albers JJ
PROVIDER: S-EPMC6421629 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Life science alliance 20190315 2
Adoptive transfer of TCR transgenic T cells holds great promise for treating various cancers. So far, mainly semi-randomly integrating vectors have been used to genetically modify T cells. These carry the risk of insertional mutagenesis, and the sole addition of an exogenous TCR potentially results in the mispairing of TCR chains with endogenous ones. Established approaches using nonviral vectors, such as transposons, already reduce the risk of insertional mutagenesis but have not accomplished s ...[more]