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Dermal tissue remodeling and non-osmotic sodium storage in kidney patients.

ABSTRACT: BACKGROUND:Excess dietary sodium is not only excreted by the kidneys, but can also be stored by non-osmotic binding with glycosaminoglycans in dermal connective tissue. Such storage has been associated with dermal inflammation and lymphangiogenesis. We aim to investigate if skin storage of sodium is increased in kidney patients and if this storage is associated with clinical parameters of sodium homeostasis and dermal tissue remodeling. METHODS:Abdominal skin tissue of 12 kidney patients (5 on hemodialysis) and 12 healthy kidney donors was obtained during surgery. Skin biopsies were processed for dermal sodium measurement by atomic absorption spectroscopy, and evaluated for CD68+ macrophages, CD3+ T-cells, collagen I, podoplanin?+?lymph vessels, and glycosaminoglycans by qRT-PCR and immunohistochemistry. RESULTS:Dermal sodium content of kidney patients did not differ from healthy individuals, but was inversely associated with plasma sodium values (p?

SUBMITTER: Hijmans RS

PROVIDER: S-EPMC6421653 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Dermal tissue remodeling and non-osmotic sodium storage in kidney patients.

Hijmans Ryanne S RS van Londen Marco M Sarpong Kwaku A KA Bakker Stephan J L SJL Navis Gerjan J GJ Storteboom Twan T R TTR de Jong Wilhelmina H A WHA Pol Robert A RA van den Born Jacob J

Journal of translational medicine 20190318 1

<h4>Background</h4>Excess dietary sodium is not only excreted by the kidneys, but can also be stored by non-osmotic binding with glycosaminoglycans in dermal connective tissue. Such storage has been associated with dermal inflammation and lymphangiogenesis. We aim to investigate if skin storage of sodium is increased in kidney patients and if this storage is associated with clinical parameters of sodium homeostasis and dermal tissue remodeling.<h4>Methods</h4>Abdominal skin tissue of 12 kidney p ...[more]

PMID: 30885222

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Dermal tissue remodeling and non-osmotic sodium storage in kidney patients.

Publications

Dermal tissue remodeling and non-osmotic sodium storage in kidney patients.

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