Associations between ADIPOQ polymorphisms and coronary artery disease: a meta-analysis.

ABSTRACT: BACKGROUND:Whether adiponectin (ADIPOQ) polymorphisms are associated with coronary artery disease (CAD) remain controversial. Therefore, we performed this meta-analysis to better explore potential roles of ADIPOQ polymorphisms in CAD. METHODS:PubMed, Web of Science, Embase and CNKI were searched for eligible studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. RESULTS:Totally 45 studies were included for pooled analyses. A significant association with the susceptibility to CAD was detected for rs2241766 (dominant model: p?=?0.0009, OR?=?0.82, 95%CI 0.73-0.92; recessive model: p?=?0.04, OR?=?1.29, 95%CI 1.02-1.64; allele model: p?

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6421689 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature