Ontology highlight
ABSTRACT:
SUBMITTER: Zhou T
PROVIDER: S-EPMC6421865 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Zhou Tongqing T Zheng Anqi A Baxa Ulrich U Chuang Gwo-Yu GY Georgiev Ivelin S IS Kong Rui R O'Dell Sijy S Shahzad-Ul-Hussan Syed S Shen Chen-Hsiang CH Tsybovsky Yaroslav Y Bailer Robert T RT Gift Syna K SK Louder Mark K MK McKee Krisha K Rawi Reda R Stevenson Catherine H CH Stewart-Jones Guillaume B E GBE Taft Justin D JD Waltari Eric E Yang Yongping Y Zhang Baoshan B Shivatare Sachin S SS Shivatare Vidya S VS Lee Chang-Chun D CD Wu Chung-Yi CY Mullikin James C JC Bewley Carole A CA Burton Dennis R DR Polonis Victoria R VR Shapiro Lawrence L Wong Chi-Huey CH Mascola John R JR Kwong Peter D PD Wu Xueling X
Immunity 20180313 3
Virtually the entire surface of the HIV-1-envelope trimer is recognized by neutralizing antibodies, except for a highly glycosylated region at the center of the "silent face" on the gp120 subunit. From an HIV-1-infected donor, #74, we identified antibody VRC-PG05, which neutralized 27% of HIV-1 strains. The crystal structure of the antigen-binding fragment of VRC-PG05 in complex with gp120 revealed an epitope comprised primarily of N-linked glycans from N262, N295, and N448 at the silent face ce ...[more]