Hemochromatosis (HFE) Gene Variants Are Associated with Increased Mitochondrial DNA Levels During HIV-1 Infection and Antiretroviral Therapy.
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ABSTRACT:
SUBMITTER: Kallianpur AR
PROVIDER: S-EPMC6421985 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
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Hemochromatosis (HFE) Gene Variants Are Associated with Increased Mitochondrial DNA Levels During HIV-1 Infection and Antiretroviral Therapy.
Kallianpur Asha R AR Gerschenson Mariana M Hulgan Todd T Kaur Harpreet H Clifford David B DB Haas David W DW Murdock Deborah G DG McArthur Justin C JC Samuels David C DC Simpson David M DM
AIDS research and human retroviruses 20180822 11
Some HIV-associated complications involve mitochondrial dysfunction and may be less common in individuals with iron-loading HFE (hemochromatosis gene) variants. We evaluated HFE 845A and 187G alleles in relation to mitochondrial DNA (mtDNA) levels in peripheral blood mononuclear cells from 85 individuals with HIV infection on uninterrupted antiretroviral therapy (ART) for 15 or more consecutive weeks. Carriers of HFE gene variants (N = 24) had significantly higher mtDNA levels than noncarriers ( ...[more]
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