Ontology highlight
ABSTRACT:
SUBMITTER: Bauzon M
PROVIDER: S-EPMC6422391 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Bauzon Maxine M Drake Penelope M PM Barfield Robyn M RM Cornali Brandon M BM Rupniewski Igor I Rabuka David D
Oncoimmunology 20190122 4
Oncology treatment has been revolutionized by the introduction of immune checkpoint inhibitor drugs, which enable 20-40% of patients to generate anti-tumor immune responses. Combination treatment approaches with chemotherapeutic drugs may enable responses in the remaining patient cohorts. In this regard, a handful of drugs are promising due to their ability to induce immunogenic cell death in target cells. However, these agents are systemically delivered and indiscriminately cytotoxic to prolife ...[more]