Ontology highlight
ABSTRACT:
SUBMITTER: Zhou ZH
PROVIDER: S-EPMC6422493 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Zhou Zhi-Hang ZH Wang Qing-Liang QL Mao Lin-Hong LH Li Xiao-Qin XQ Liu Peng P Song Jin-Wen JW Liu Xue X Xu Feng F Lei Jing J He Song S
Cell cycle (Georgetown, Tex.) 20190211 4
The acidic extracellular microenvironment, namely acidosis, is a biochemical hallmark of solid tumors. However, the tumorigenicity, metastatic potential, gene expression profile and chromatin accessibility of acidosis-adapted colorectal cancer cells remain unknown. The colorectal cancer cell SW620 was cultured in acidic medium (pH 6.5) for more than 3 months to be acidosis-adapted (SW620-AA). In comparison to parental cells, SW620-AA cells exhibit enhanced tumorigenicity and liver metastatic pot ...[more]