Ontology highlight
ABSTRACT:
SUBMITTER: Penning TM
PROVIDER: S-EPMC6422768 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Molecular and cellular endocrinology 20180919
Aldo-Keto-Reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase (HSD)/prostaglandin (PG) F<sub>2α</sub> synthase) is the only 17β-HSD that is not a short-chain dehydrogenase/reductase. By acting as a 17-ketosteroid reductase, AKR1C3 produces potent androgens in peripheral tissues which activate the androgen receptor (AR) or act as substrates for aromatase. AKR1C3 is implicated in the production of androgens in castration-resistant prostate cancer (CRPC) and polycystic ovarian syndrome; and is i ...[more]