Ontology highlight
ABSTRACT:
SUBMITTER: Lin WC
PROVIDER: S-EPMC6422952 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Lin Wan-Chen WC Tsai Ming-Chi MC Rajappa Rajit R Kramer Richard H RH
Journal of the American Chemical Society 20180606 24
Photoswitchable neurotransmitter receptors are powerful tools for precise manipulation of neural signaling. However, their applications for slow or long-lasting biological events are constrained by fast thermal relaxation of cis-azobenzene. We address this issue by modifying the ortho positions of azobenzene used in the tethered ligand. In cultured cells and intact brain tissue, conjugating inhibitory neurotransmitter receptors with one of the derivatives, dMPC1, allows bidirectional receptor co ...[more]