Ontology highlight
ABSTRACT:
SUBMITTER: Economopoulou P
PROVIDER: S-EPMC6423363 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Economopoulou Panagiota P Kotoula Vassiliki V Koliou Georgia-Angeliki GA Papadopoulou Kyriaki K Christodoulou Christos C Pentheroudakis George G Lazaridis Georgios G Arapantoni-Dadioti Petroula P Koutras Angelos A Bafaloukos Dimitris D Papakostas Pavlos P Patsea Helen H Pavlakis Kitty K Pectasides Dimitrios D Kotsakis Athanasios A Razis Evangelia E Aravantinos Gerasimos G Samantas Epaminondas E Kalogeras Konstantine T KT Economopoulos Theofanis T Psyrri Amanta A Fountzilas George G
Translational oncology 20190314 5
<h4>Background</h4>Src, CDKN1B, and JAK2 play a crucial role in the coordination of cell signaling pathways. In the present study, we aim to investigate the prognostic significance of these biomarkers in HER2-positive metastatic breast cancer (MBC) patients treated with trastuzumab (T).<h4>Methods</h4>Formalin-fixed paraffin-embedded tumor tissue samples from 197 patients with HER2-positive MBC treated with T were retrospectively collected. All tissue samples were centrally assessed for ER, PgR, ...[more]