Dataset Information

The African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension (African-PREDICT): Design, recruitment and initial examination.

ABSTRACT:

Background

Globally hypertension is stabilising, but in sub-Saharan Africa the incidence of hypertension remains on an increase. Although this might be attributed to poor healthcare and ineffective antihypertensive treatment, there is a limited understanding of population and individual-specific cardiovascular pathophysiology - necessary for effective prevention and treatment strategies in Africa. As there is a lack of longitudinal studies tracking the early pathophysiological development of hypertension in black populations, the African-PREDICT study was initiated. The purpose of this paper is to describe the detailed methodology and baseline cohort profile of the study.

Methods and results

From 2013 to 2017, the study included 1202 black ( N = 606) and white ( N = 596) men and women (aged 20-30 years) from South Africa - screened to be healthy and clinic normotensive. At baseline, and each 5-year follow-up examination, detailed measures of health behaviours, cardiovascular profile and organ damage are taken. Also, comprehensive biological sampling for the 'omics' and biomarkers is performed. Overall, the baseline black and white cohort presented with similar ages, clinic and 24-hour blood pressures, but black adults had lower socioeconomic status and higher central systolic blood pressure than white individuals.

Conclusions

The prospective African-PREDICT study in young black and white adults will contribute to a clear understanding of early cardiovascular disease development.

SUBMITTER: Schutte AE

PROVIDER: S-EPMC6423686 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Publications

The African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension (African-PREDICT): Design, recruitment and initial examination.

Schutte Aletta E AE Gona Philimon N PN Delles Christian C Uys Aletta S AS Burger Adele A Mels Catharina Mc CM Kruger Ruan R Smith Wayne W Fourie Carla Mt CM Botha Shani S Lammertyn Leandi L van Rooyen Johannes M JM Gafane-Matemane Lebo F LF Mokwatsi Gontse G GG Breet Yolandi Y Kruger H Salome HS Zyl Tertia van TV Pieters Marlien M Zandberg Lizelle L Louw Roan R Moss Sarah J SJ Khumalo Itumeleng P IP Huisman Hugo W HW

European journal of preventive cardiology 20190106 5

<h4>Background</h4>Globally hypertension is stabilising, but in sub-Saharan Africa the incidence of hypertension remains on an increase. Although this might be attributed to poor healthcare and ineffective antihypertensive treatment, there is a limited understanding of population and individual-specific cardiovascular pathophysiology - necessary for effective prevention and treatment strategies in Africa. As there is a lack of longitudinal studies tracking the early pathophysiological developmen ...[more]

PMID: 30681377

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Dataset Information

The African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension (African-PREDICT): Design, recruitment and initial examination.

Background

Methods and results

Conclusions

Publications

The African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension (African-PREDICT): Design, recruitment and initial examination.

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