Ontology highlight
ABSTRACT:
SUBMITTER: Hubler Z
PROVIDER: S-EPMC6423962 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Hubler Zita Z Allimuthu Dharmaraja D Bederman Ilya I Elitt Matthew S MS Madhavan Mayur M Allan Kevin C KC Shick H Elizabeth HE Garrison Eric E T Karl Molly M Factor Daniel C DC Nevin Zachary S ZS Sax Joel L JL Thompson Matthew A MA Fedorov Yuriy Y Jin Jing J Wilson William K WK Giera Martin M Bracher Franz F Miller Robert H RH Tesar Paul J PJ Adams Drew J DJ
Nature 20180725 7718
Regeneration of myelin is mediated by oligodendrocyte progenitor cells-an abundant stem cell population in the central nervous system (CNS) and the principal source of new myelinating oligodendrocytes. Loss of myelin-producing oligodendrocytes in the CNS underlies a number of neurological diseases, including multiple sclerosis and diverse genetic diseases<sup>1-3</sup>. High-throughput chemical screening approaches have been used to identify small molecules that stimulate the formation of oligod ...[more]