Prognostic impact of TTF-1 expression in patients with stage IV lung adenocarcinomas.

ABSTRACT:

Objectives

Thyroid transcription factor 1 (TTF-1) is routinely tested in the diagnostic evaluation of suspected lung cancers, is commonly expressed by lung adenocarcinomas, and may modulate lung cancer biology. We examined the role of TTF-1 as a predictive and prognostic marker in patients with advanced lung adenocarcinomas.

Materials and methods

We analyzed clinical, pathologic, and molecular features, treatments received, and overall survival obtained from the medical records of 479 consecutive patients at a single site with stage IV lung adenocarcinomas and evaluable TTF-1 expression. TTF-1 expression was determined by immunohistochemistry using antibody 8G7G3/1.

Results and conclusion

TTF-1 expression was evaluable in 479 (75%) of all patients reviewed, and was po

SUBMITTER: Schilsky JB 

PROVIDER: S-EPMC6423973 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature