Ontology highlight
ABSTRACT:
SUBMITTER: Song X
PROVIDER: S-EPMC6423983 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Song Xinhua X Liu Xianqiong X Wang Haichuan H Wang Jingxiao J Qiao Yu Y Cigliano Antonio A Utpatel Kirsten K Ribback Silvia S Pilo Maria G MG Serra Marina M Gordan John D JD Che Li L Zhang Shanshan S Cossu Antonio A Porcu Alberto A Pascale Rosa M RM Dombrowski Frank F Hu Hongbo H Calvisi Diego F DF Evert Matthias M Chen Xin X
Clinical cancer research : an official journal of the American Association for Cancer Research 20180703 1
<h4>Purpose</h4>Intrahepatic cholangiocarcinoma (ICC) is an aggressive cancer type, lacking effective therapies and associated with a dismal prognosis. Palbociclib is a selective CDK4/6 inhibitor, which has been shown to suppress cell proliferation in many experimental cancer models. Recently, we demonstrated that pan-mTOR inhibitors, such as MLN0128, effectively induce apoptosis, although have limited efficacy in restraining proliferation of ICC cells. Here, we tested the hypothesis that palboc ...[more]