Ontology highlight
ABSTRACT:
SUBMITTER: Binder ZA
PROVIDER: S-EPMC6424337 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Cancer cell 20180701 1
We explored the clinical and pathological impact of epidermal growth factor receptor (EGFR) extracellular domain missense mutations. Retrospective assessment of 260 de novo glioblastoma patients revealed a significant reduction in overall survival of patients having tumors with EGFR mutations at alanine 289 (EGFR<sup>A289D/T/V</sup>). Quantitative multi-parametric magnetic resonance imaging analyses indicated increased tumor invasion for EGFR<sup>A289D/T/V</sup> mutants, corroborated in mice bea ...[more]