Dataset Information

Pancreatic 18F-FDG uptake is increased in type 2 diabetes patients compared to non-diabetic controls.

ABSTRACT:

Introduction

Increasing evidence indicates that the development of type 2 diabetes is driven by chronic low grade beta-cell inflammation. However, it is unclear whether pancreatic inflammation can be noninvasively visualized in type 2 diabetes patients. We aimed to assess pancreatic 18F-FDG uptake in type 2 diabetes patients and controls using 18F-fluorodeoxylglucose positron emission tomography/computed tomography (18F-FDG PET/CT).

Material and methods

In this retrospective cross-sectional study, we enrolled 20 type 2 diabetes patients and 65 controls who had undergone a diagnostic 18F-FDG PET/CT scan and obtained standardized uptake values (SUVs) of pancreas and muscle. Pancreatic SUV was adjusted for background uptake in muscle and for fasting blood glucose concentrations.

Results

The maximum pancreatic SUVs adjusted for background muscle uptake (SUVmax.m) and fasting blood glucose concentration (SUVglucose) were significantly higher in diabetes patients compared to controls (median 2.86 [IQR 2.24-4.36] compared to 2.15 [IQR 1.51-2.83], p = 0.006 and median 2.76 [IQR 1.18-4.34] compared to 1.91 [IQR 1.27-2.55], p<0.001, respectively). In linear regression adjusting for age and body mass index, diabetes remained the main predictor of SUVmax.m and SUVglucose.

Conclusion

Pancreatic 18F-FDG uptake adjusted for background muscle uptake and fasting blood glucose concentration was significantly increased in type 2 diabetes patients.

SUBMITTER: Bakker GJ

PROVIDER: S-EPMC6424390 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

Pancreatic 18F-FDG uptake is increased in type 2 diabetes patients compared to non-diabetic controls.

Bakker Guido J GJ Vanbellinghen Manon C MC Scheithauer Torsten P TP Verchere C Bruce CB Stroes Erik S ES Timmers Nyanza K L M NKLM Herrema Hilde H Nieuwdorp Max M Verberne Hein J HJ van Raalte Daniël H DH

PloS one 20190319 3

<h4>Introduction</h4>Increasing evidence indicates that the development of type 2 diabetes is driven by chronic low grade beta-cell inflammation. However, it is unclear whether pancreatic inflammation can be noninvasively visualized in type 2 diabetes patients. We aimed to assess pancreatic 18F-FDG uptake in type 2 diabetes patients and controls using 18F-fluorodeoxylglucose positron emission tomography/computed tomography (18F-FDG PET/CT).<h4>Material and methods</h4>In this retrospective cross ...[more]

PMID: 30889184

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Dataset Information

Pancreatic 18F-FDG uptake is increased in type 2 diabetes patients compared to non-diabetic controls.

Introduction

Material and methods

Results

Conclusion

Publications

Pancreatic 18F-FDG uptake is increased in type 2 diabetes patients compared to non-diabetic controls.

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