Ontology highlight
ABSTRACT:
SUBMITTER: She J
PROVIDER: S-EPMC6424560 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
She Ji J Zeng Weizhong W Guo Jiangtao J Chen Qingfeng Q Bai Xiao-Chen XC Jiang Youxing Y
eLife 20190312
Mammalian two-pore channels (TPCs) regulate the physiological functions of the endolysosome. Here we present cryo-EM structures of human TPC2 (HsTPC2), a phosphatidylinositol 3,5-bisphosphate (PI(3,5)P<sub>2</sub>)-activated, Na<sup>+</sup> selective channel, in the ligand-bound and apo states. The apo structure captures the closed conformation, while the ligand-bound form features the channel in both open and closed conformations. Combined with functional analysis, these structures provide insi ...[more]