Ontology highlight
ABSTRACT:
SUBMITTER: Gogl G
PROVIDER: S-EPMC6424611 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Gógl Gergő G Biri-Kovács Beáta B Durbesson Fabien F Jane Pau P Nomine Yves Y Kostmann Camille C Bilics Viktória V Simon Márton M Reményi Attila A Vincentelli Renaud R Trave Gilles G Nyitray László L
Journal of molecular biology 20190203 6
Phosphorylation of short linear peptide motifs is a widespread process for the dynamic regulation of protein-protein interactions. However, the global impact of phosphorylation events on the protein-protein interactome is rarely addressed. The disordered C-terminal tail of ribosomal S6 kinase 1 (RSK1) binds to PDZ domain-containing scaffold proteins, and it harbors a phosphorylatable PDZ-binding motif (PBM) responsive to epidermal growth factor stimulation. Here, we examined binding of two versi ...[more]