Effects of hydration on plasma copeptin, glycemia and gluco-regulatory hormones: a water intervention in humans.

ABSTRACT:

Purpose

High plasma copeptin, a marker of vasopressin, predicts diabetes mellitus. We tested if copeptin could be suppressed by increased water intake in healthy individuals, and if a water-induced change in copeptin was accompanied by altered concentrations of glucose, insulin or glucagon.

Methods

Thirty-nine healthy individuals underwent, in random order, 1 week of high water intake (3 L/day on top of habitual intake) and 1 week of normal (habitual) fluid intake (control). Fasting plasma concentrations of copeptin, glucose, insulin and glucagon were compared between the ends of both periods. Furthermore, acute copeptin kinetics were mapped for 4 h after ingestion of 1 L of water.

Results

After acute intake of 1 L water, copeptin was significantly reduced within 30 m

SUBMITTER: Enhorning S 

PROVIDER: S-EPMC6424930 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature