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Cell maps on the human genome.

ABSTRACT:

Background

We have previously described evidence for a statistically significant, global, supra-chromosomal representation of the human body that appears to stretch over the entire genome.

Results

Here, we extend the genome mapping model, zooming down to the typical individual animal cell. Its cellular organization appears to be significantly mapped onto the human genome: Evidence is reported for a "cellunculus" - on the model of a homunculus, on the H. sapiens genome.

Conclusions

Basic cell structure turns out to map similarly onto the total genome, mirrored via genes that express in particular cell organelles (e.g., "nuclear membrane"). Similar cell maps may also appear on individual chromosomes that map topologically on the dorsoventral body axis. This seems to constitute some of the basic structural and functional organization of nucleus and chromosome architecture.

SUBMITTER: Cherniak C

PROVIDER: S-EPMC6425595 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Cell maps on the human genome.

Cherniak Christopher C Rodriguez-Esteban Raul R

Molecular cytogenetics 20190320

<h4>Background</h4>We have previously described evidence for a statistically significant, global, supra-chromosomal representation of the human body that appears to stretch over the entire genome.<h4>Results</h4>Here, we extend the genome mapping model, zooming down to the typical individual animal cell. Its cellular organization appears to be significantly mapped onto the human genome: Evidence is reported for a "cellunculus" - on the model of a homunculus, on the <i>H. sapiens</i> genome.<h4>C ...[more]

PMID: 30930962

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