Ontology highlight
ABSTRACT:
SUBMITTER: Quigley DA
PROVIDER: S-EPMC6425931 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Quigley David A DA Dang Ha X HX Zhao Shuang G SG Lloyd Paul P Aggarwal Rahul R Alumkal Joshi J JJ Foye Adam A Kothari Vishal V Perry Marc D MD Bailey Adina M AM Playdle Denise D Barnard Travis J TJ Zhang Li L Zhang Jin J Youngren Jack F JF Cieslik Marcin P MP Parolia Abhijit A Beer Tomasz M TM Thomas George G Chi Kim N KN Gleave Martin M Lack Nathan A NA Zoubeidi Amina A Reiter Robert E RE Rettig Matthew B MB Witte Owen O Ryan Charles J CJ Fong Lawrence L Kim Won W Friedlander Terence T Chou Jonathan J Li Haolong H Das Rajdeep R Li Hui H Moussavi-Baygi Ruhollah R Goodarzi Hani H Gilbert Luke A LA Lara Primo N PN Evans Christopher P CP Goldstein Theodore C TC Stuart Joshua M JM Tomlins Scott A SA Spratt Daniel E DE Cheetham R Keira RK Cheng Donavan T DT Farh Kyle K Gehring Julian S JS Hakenberg Jörg J Liao Arnold A Febbo Philip G PG Shon John J Sickler Brad B Batzoglou Serafim S Knudsen Karen E KE He Housheng H HH Huang Jiaoti J Wyatt Alexander W AW Dehm Scott M SM Ashworth Alan A Chinnaiyan Arul M AM Maher Christopher A CA Small Eric J EJ Feng Felix Y FY
Cell 20180719 3
While mutations affecting protein-coding regions have been examined across many cancers, structural variants at the genome-wide level are still poorly defined. Through integrative deep whole-genome and -transcriptome analysis of 101 castration-resistant prostate cancer metastases (109X tumor/38X normal coverage), we identified structural variants altering critical regulators of tumorigenesis and progression not detectable by exome approaches. Notably, we observed amplification of an intergenic e ...[more]