Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC6425953 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Liu Yajun Y McDonald Nathan A NA Naegele Shelby M SM Gould Kathleen L KL Wu Jian-Qiu JQ
Cell reports 20190301 10
F-BAR proteins bind the plasma membrane (PM) to scaffold and organize the actin cytoskeleton. To understand how F-BAR proteins achieve their PM association, we studied the localization of a Schizosaccharomyces pombe F-BAR protein Rga7, which requires the coiled-coil protein Rng10 for targeting to the division site during cytokinesis. We find that the Rga7 F-BAR domain directly binds a motif in Rng10 simultaneously with the PM, and that an adjacent Rng10 motif independently binds the PM. Together ...[more]