Ontology highlight
ABSTRACT:
SUBMITTER: Guo P
PROVIDER: S-EPMC6426465 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Guo Peng P Yang Jiang J Liu Daxing D Huang Lan L Fell Gillian G Huang Jing J Moses Marsha A MA Auguste Debra T DT
Science advances 20190320 3
Distinguishing malignant cells from non-neoplastic ones is a major challenge in triple-negative breast cancer (TNBC) treatment. Here, we developed a complementary targeting strategy that uses precisely matched, multivalent ligand-receptor interactions to recognize and target TNBC tumors at the primary site and metastatic lesions. We screened a panel of cancer cell surface markers and identified intercellular adhesion molecule-1 (ICAM1) and epithelial growth factor receptor (EGFR) as optimal cand ...[more]