Ontology highlight
ABSTRACT:
SUBMITTER: Colin-York H
PROVIDER: S-EPMC6426652 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Colin-York Huw H Javanmardi Yousef Y Skamrahl Mark M Kumari Sudha S Chang Veronica T VT Khuon Satya S Taylor Aaron A Chew Teng-Leong TL Betzig Eric E Moeendarbary Emad E Cerundolo Vincenzo V Eggeling Christian C Fritzsche Marco M
Cell reports 20190301 12
Cytoskeletal actin dynamics is essential for T cell activation. Here, we show evidence that the binding kinetics of the antigen engaging the T cell receptor influences the nanoscale actin organization and mechanics of the immune synapse. Using an engineered T cell system expressing a specific T cell receptor and stimulated by a range of antigens, we found that the peak force experienced by the T cell receptor during activation was independent of the unbinding kinetics of the stimulating antigen. ...[more]