Overlapping features of rapidly progressive osteoarthrosis and Charcot arthropathy.
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ABSTRACT:
SUBMITTER: Sono T
PROVIDER: S-EPMC6426701 | biostudies-literature | 2019 May-Jun
REPOSITORIES: biostudies-literature
Publications
Overlapping features of rapidly progressive osteoarthrosis and Charcot arthropathy.
Sono Takashi T Meyers Carolyn A CA Miller Daniel D Ding Catherine C McCarthy Edward F EF James Aaron W AW
Journal of orthopaedics 20190312 3
Nerve growth factor (NGF) is the primary neurotrophin in the skeleton and a central mediator of skeletal pain. Recent trials of anti-NGF neutralizing antibodies have resulted in infrequent but well-described incidence of rapidly progressive osteoarthrosis (RPOA). Neuropathy, whether from syphilis or diabetes, is also associated with severe joint destruction, known as neuroarthropathy or Charcot joint. These commonalities of severe joint destruction with either loss of a neurotrophin (anti-NGF) o ...[more]
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