Immune cell infiltration as a biomarker for the diagnosis and prognosis of stage I-III colon cancer.
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ABSTRACT:
SUBMITTER: Zhou R
PROVIDER: S-EPMC6426802 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
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Immune cell infiltration as a biomarker for the diagnosis and prognosis of stage I-III colon cancer.
Zhou Rui R Zhang Jingwen J Zeng Dongqiang D Sun Huiying H Rong Xiaoxiang X Shi Min M Bin Jianping J Liao Yulin Y Liao Wangjun W
Cancer immunology, immunotherapy : CII 20181219 3
Tumour-infiltrating immune cells are a source of important prognostic information for patients with resectable colon cancer. We developed a novel immune model based on systematic assessments of the immune landscape inferred from bulk tumor transcriptomes of stage I-III colon cancer patients. The "Cell type Identification By Estimating Relative Subsets Of RNA Transcripts (CIBERSORT)" algorithm was used to estimate the fraction of 22 immune cell types from six microarray public datasets. The rando ...[more]
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Project description:ObjectiveHNRNPA2B1, one of the regulator of m6A methylation, is involved in a wide range of physiological processes. However, the aberrant expression of HNRNPA2B1 in Breast Cancer (BC) and its clinical significance still need to be further studied.MethodsWe used related databases to analyze the relationship between HNRNPA2B1 and BC by bioinformatics. Then, we further detected the expression of HNRNPA2B1 by immunohistochemical method, and analyzed the relationship between it and the prognosis of breast cancer by COX regression method.ResultsIn the study, we found that the expression level of HNRNPA2B1 in breast cancer (BC) was significantly higher than that in normal breast tissues. In addition, the expression level of HNRNPA2B1 in BC samples was significantly correlated with clinical indexes such as TNM stage. The Cox analysis revealed that the expression of HNRNPA2B1 in BC had significant clinical prognostic value. The results of immune infiltration of HNRNPA2B1 showed that there was a significant correlation between HNRNPA2B1 and immune cell subsets.ConclusionOur results show that the expression of HNRNPA2B1 in BC has important clinical diagnostic significance and high expression may be related with poor clinical outcome of BC. This helps to provide us with a new direction of BC targeted therapy.
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