Ontology highlight
ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC6426848 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Liu Hao H Du Feng F Sun Lina L Wu Qingfeng Q Wu Jian J Tong Mingfu M Wang Xin X Wang Qi Q Cao Tianyu T Gao Xiaoliang X Cao Jiayi J Wu Nan N Nie Yongzhan Y Fan Daiming D Lu Yuanyuan Y Zhao Xiaodi X
Cell death & disease 20190115 2
Transcription factors (TFs) and microRNAs (miRNAs) are tightly linked to each other in tumor development and progression, but their interactions in gastric cancer (GC) metastasis remain elusive. Here we report a novel suppressive role of GATA6 in inhibiting GC metastasis by transactivating miR-520b. We found that GATA6 expression was significantly downregulated in metastatic GC cells and tissues and that its downregulation was correlated with a poor GC prognosis. Overexpression of GATA6 suppress ...[more]