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Emerging of Explosive Speech after Olanzapine in Multiple System Atrophy Patient.

ABSTRACT: Background:Cerebellum has an important role in sensorimotor control including speech. Multiple system atrophy (MSA) is a sporadic and rapidly progressive neurodegenerative disorder that presents with autonomic failure in combination with Parkinsonism or cerebellar ataxia. Case Report:We report a case of MSA-cerebellum subtype associated with emergence of irreversible explosive speech following olanzapine therapy. Conclusions:Further investigation into speech problems in MSA according to subtype and disease severity is needed, and side effects of olanzapine therapy should also be considered.

SUBMITTER: Kim YS

PROVIDER: S-EPMC6427994 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Emerging of Explosive Speech after Olanzapine in Multiple System Atrophy Patient.

Kim Yong Sung YS Kim Seung Jae SJ Lee Jongmin J Kim Hee-Jin HJ

Dementia and neurocognitive disorders 20180326 1

<h4>Background</h4>Cerebellum has an important role in sensorimotor control including speech. Multiple system atrophy (MSA) is a sporadic and rapidly progressive neurodegenerative disorder that presents with autonomic failure in combination with Parkinsonism or cerebellar ataxia.<h4>Case report</h4>We report a case of MSA-cerebellum subtype associated with emergence of irreversible explosive speech following olanzapine therapy.<h4>Conclusions</h4>Further investigation into speech problems in MSA ...[more]

PMID: 30906390

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Project description:Multiple system atrophy (MSA) is an orphan, fatal, adult-onset neurodegenerative disorder of uncertain etiology that is clinically characterized by various combinations of parkinsonism, cerebellar, autonomic, and motor dysfunction. MSA is an ?-synucleinopathy with specific glioneuronal degeneration involving striatonigral, olivopontocerebellar, and autonomic nervous systems but also other parts of the central and peripheral nervous systems. The major clinical variants correlate with the morphologic phenotypes of striatonigral degeneration (MSA-P) and olivopontocerebellar atrophy (MSA-C). While our knowledge of the molecular pathogenesis of this devastating disease is still incomplete, updated consensus criteria and combined fluid and imaging biomarkers have increased its diagnostic accuracy. The neuropathologic hallmark of this unique proteinopathy is the deposition of aberrant ?-synuclein in both glia (mainly oligodendroglia) and neurons forming glial and neuronal cytoplasmic inclusions that cause cell dysfunction and demise. In addition, there is widespread demyelination, the pathogenesis of which is not fully understood. The pathogenesis of MSA is characterized by propagation of misfolded ?-synuclein from neurons to oligodendroglia and cell-to-cell spreading in a "prion-like" manner, oxidative stress, proteasomal and mitochondrial dysfunction, dysregulation of myelin lipids, decreased neurotrophic factors, neuroinflammation, and energy failure. The combination of these mechanisms finally results in a system-specific pattern of neurodegeneration and a multisystem involvement that are specific for MSA. Despite several pharmacological approaches in MSA models, addressing these pathogenic mechanisms, no effective neuroprotective nor disease-modifying therapeutic strategies are currently available. Multidisciplinary research to elucidate the genetic and molecular background of the deleterious cycle of noxious processes, to develop reliable biomarkers and targets for effective treatment of this hitherto incurable disorder is urgently needed.

Dataset Information

Emerging of Explosive Speech after Olanzapine in Multiple System Atrophy Patient.

Publications

Emerging of Explosive Speech after Olanzapine in Multiple System Atrophy Patient.

Similar Datasets

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