Spherical Nucleic Acid Nanoparticles: Therapeutic Potential.
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ABSTRACT:
SUBMITTER: Kapadia CH
PROVIDER: S-EPMC6428072 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Spherical Nucleic Acid Nanoparticles: Therapeutic Potential.
Kapadia Chintan H CH Melamed Jilian R JR Day Emily S ES
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20180801 4
Spherical nucleic acids (SNAs) are highly oriented, well organized, polyvalent structures of nucleic acids conjugated to hollow or solid core nanoparticles. Because they can transfect many tissue and cell types without toxicity, induce minimum immune response, and penetrate various biological barriers (such as the skin, blood-brain barrier, and blood-tumor barrier), they have become versatile tools for the delivery of nucleic acids, drugs, and proteins for various therapeutic purposes. This arti ...[more]
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