Ontology highlight
ABSTRACT:
SUBMITTER: Castro W
PROVIDER: S-EPMC6428260 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Nature immunology 20180702 8
Regulatory factor X 7 (Rfx7) is an uncharacterized transcription factor belonging to a family involved in ciliogenesis and immunity. Here, we found that deletion of Rfx7 leads to a decrease in natural killer (NK) cell maintenance and immunity in vivo. Genomic approaches showed that Rfx7 coordinated a transcriptional network controlling cell metabolism. Rfx7<sup>-/-</sup> NK lymphocytes presented increased size, granularity, proliferation, and energetic state, whereas genetic reduction of mTOR ac ...[more]