Ontology highlight
ABSTRACT:
SUBMITTER: Johnson SC
PROVIDER: S-EPMC6428290 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Johnson Simon C SC Pan Amanda A Sun Grace X GX Freed Arielle A Stokes Julia C JC Bornstein Rebecca R Witkowski Michael M Li Li L Ford Jeremy M JM Howard Christopher R A CRA Sedensky Margaret M MM Morgan Philip G PG
PloS one 20190321 3
Routine general anesthesia is considered to be safe in healthy individuals. However, pre-clinical studies in mice, rats, and monkeys have repeatedly demonstrated that exposure to anesthetic agents during early post-natal periods can lead to acute neurotoxicity. More concerning, later-life defects in cognition, assessed by behavioral assays for learning and memory, have been reported. Although the potential for anesthetics to damage the neonatal brain is well-documented, the clinical significance ...[more]