Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways.
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ABSTRACT:
SUBMITTER: Steele CD
PROVIDER: S-EPMC6428691 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways.
Steele Christopher D CD Tarabichi Maxime M Oukrif Dahmane D Webster Amy P AP Ye Hongtao H Fittall Matthew M Lombard Patrick P Martincorena Iñigo I Tarpey Patrick S PS Collord Grace G Haase Kerstin K Strauss Sandra J SJ Berisha Fitim F Vaikkinen Heli H Dhami Pawan P Jansen Marnix M Behjati Sam S Amary M Fernanda MF Tirabosco Roberto R Feber Andrew A Campbell Peter J PJ Alexandrov Ludmil B LB Van Loo Peter P Flanagan Adrienne M AM Pillay Nischalan N
Cancer cell 20190301 3
Undifferentiated sarcomas (USARCs) of adults are diverse, rare, and aggressive soft tissue cancers. Recent sequencing efforts have confirmed that USARCs exhibit one of the highest burdens of structural aberrations across human cancer. Here, we sought to unravel the molecular basis of the structural complexity in USARCs by integrating DNA sequencing, ploidy analysis, gene expression, and methylation profiling. We identified whole genome duplication as a prevalent and pernicious force in USARC tum ...[more]
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