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Integrative Genome-Wide Association Studies of eQTL and GWAS Data for Gout Disease Susceptibility.


ABSTRACT: There is a paucity of genome-wide association study on Han Chinese gout patients. We performed a genome-wide association meta-analysis on two Taiwanese cohorts consisting of 758 gout cases and 14166 controls of Han Chinese ancestry. All the participants were recruited from the Taiwan Biobank. For pathway analysis, we applied ICSNPathway (Identify candidate Causal SNPs and Pathways) analysis, and to investigate whether expression-associated genetic variants contribute to gout susceptibility, we systematically integrated lymphoblastoid expression quantitative trait loci (eQTL) and genome-wide association data of gout using Sherlock, a Bayesian statistical frame-work. In the meta-analysis, we found 4 SNPs that reached genome-wide statistical significance (P?

SUBMITTER: Lee MG 

PROVIDER: S-EPMC6428872 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Integrative Genome-Wide Association Studies of eQTL and GWAS Data for Gout Disease Susceptibility.

Lee Meng-Tse Gabriel MG   Hsu Tzu-Chun TC   Chen Shyr-Chyr SC   Lee Ya-Chin YC   Kuo Po-Hsiu PH   Yang Jenn-Hwai JH   Chang Hsiu-Hao HH   Lee Chien-Chang CC  

Scientific reports 20190321 1


There is a paucity of genome-wide association study on Han Chinese gout patients. We performed a genome-wide association meta-analysis on two Taiwanese cohorts consisting of 758 gout cases and 14166 controls of Han Chinese ancestry. All the participants were recruited from the Taiwan Biobank. For pathway analysis, we applied ICSNPathway (Identify candidate Causal SNPs and Pathways) analysis, and to investigate whether expression-associated genetic variants contribute to gout susceptibility, we s  ...[more]

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