Cannabinoid Signaling in the Skin: Therapeutic Potential of the "C(ut)annabinoid" System.

ABSTRACT: The endocannabinoid system (ECS) has lately been proven to be an important, multifaceted homeostatic regulator, which influences a wide-variety of physiological processes all over the body. Its members, the endocannabinoids (eCBs; e.g., anandamide), the eCB-responsive receptors (e.g., CB₁, CB₂), as well as the complex enzyme and transporter apparatus involved in the metabolism of the ligands were shown to be expressed in several tissues, including the skin. Although the best studied functions over the ECS are related to the central nervous system and to immune processes, experimental efforts over the last two decades have unambiguously confirmed that cutaneous cannabinoid ("c[ut]annabinoid") signaling is deeply involved in the maintenance of skin homeostasis, barrier formation and regenera

SUBMITTER: Toth KF 

PROVIDER: S-EPMC6429381 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature