Chloride Channels in Astrocytes: Structure, Roles in Brain Homeostasis and Implications in Disease.

ABSTRACT: Astrocytes are the most abundant cell type in the CNS (central nervous system). They exert multiple functions during development and in the adult CNS that are essential for brain homeostasis. Both cation and anion channel activities have been identified in astrocytes and it is believed that they play key roles in astrocyte function. Whereas the proteins and the physiological roles assigned to cation channels are becoming very clear, the study of astrocytic chloride channels is in its early stages. In recent years, we have moved from the identification of chloride channel activities present in astrocyte primary culture to the identification of the proteins involved in these activities, the determination of their 3D structure and attempts to gain insights about their physiological role. Here

SUBMITTER: Elorza-Vidal X 

PROVIDER: S-EPMC6429410 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature