Ontology highlight
ABSTRACT:
SUBMITTER: Jia X
PROVIDER: S-EPMC6429411 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20190311 5
The present study describes an AuPPh₃Cl/AgSbF₆-catalyzed cascade reaction between amine nucleophiles and alkynoic acids in water. This process proceeds in high step economy with water as the sole coproduct, and leads to the generation of two rings, together with the formation of three new bonds in a single operation. This green cascade process exhibits valuable features such as low catalyst loading, good to excellent yields, high efficiency in bond formation, excellent selectivity, great toleran ...[more]