Ontology highlight
ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC6429512 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Wang Wenzhi W Lei Lei L Liu Zhi Z Wang Hongbo H Meng Qingguo Q
Molecules (Basel, Switzerland) 20190301 5
Nineteen ursolic acid analogues were designed, synthesized, and evaluated for their antiproliferative activity against the Hela and MKN45 cell lines. Some compounds containing a piperazine moiety displayed moderate to high levels of antitumor activities against the tested cancer cell lines. The most potent compound shares the IC<sub>50</sub> value of 2.1 µM and 2.6 µM for the Hela and MKN45 cell lines, respectively. Further mechanism studies and in vivo antitumor studies have shown that it decre ...[more]