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Synthesis of ¹⁸F-difluoromethylarenes using aryl boronic acids, ethyl bromofluoroacetate and [¹⁸F]fluoride.

ABSTRACT: Herein, we report the radiosynthesis of ¹⁸F-difluoromethylarenes via the assembly of three components, a boron reagent, ethyl bromofluoroacetate, and cyclotron-produced non-carrier added [¹⁸F]fluoride. The two key steps are a copper-catalysed cross-coupling reaction, and a Mn-mediated ¹⁸F-fluorodecarboxylation.

SUBMITTER: Sap JBI

PROVIDER: S-EPMC6429591 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Synthesis of 18F-difluoromethylarenes using aryl boronic acids, ethyl bromofluoroacetate and [18F]fluoride.

Sap Jeroen B I JBI Wilson Thomas C TC Kee Choon Wee CW Straathof Natan J W NJW Ende Christopher W Am CWA Mukherjee Paramita P Zhang Lei L Genicot Christophe C Gouverneur Véronique V

Chemical science 20190129 11

Herein, we report the radiosynthesis of 18F-difluoromethylarenes via the assembly of three components, a boron reagent, ethyl bromofluoroacetate, and cyclotron-produced non-carrier added [18F]fluoride. The two key steps are a copper-catalysed cross-coupling reaction, and a Mn-mediated 18F-fluorodecarboxylation. ...[more]

PMID: 30996907

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| S-EPMC7246165 | biostudies-literature