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Electrochemical fluoromethylation triggered lactonizations of alkenes under semi-aqueous conditions.

ABSTRACT: An electrochemical difluoromethylation triggered lactonization of alkenes was developed for the first time. This protocol employs readily prepared CF₂HSO₂Na as the difluoromethylating reagent, affording unprecedented CF₂H-containing lactones in moderate yields. Moreover, with CF₃SO₂Na as the trifluoromethylating reagent, a wide array of CF₃-containing lactones were obtained under additional supporting electrolyte- and catalyst-free conditions.

SUBMITTER: Zhang S

PROVIDER: S-EPMC6429606 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Electrochemical fluoromethylation triggered lactonizations of alkenes under semi-aqueous conditions.

Zhang Sheng S Li Lijun L Zhang Jinjin J Zhang Junqi J Xue Mengyu M Xu Kun K

Chemical science 20190214 11

An electrochemical difluoromethylation triggered lactonization of alkenes was developed for the first time. This protocol employs readily prepared CF2HSO2Na as the difluoromethylating reagent, affording unprecedented CF2H-containing lactones in moderate yields. Moreover, with CF3SO2Na as the trifluoromethylating reagent, a wide array of CF3-containing lactones were obtained under additional supporting electrolyte- and catalyst-fre ...[more]

PMID: 30996899

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