Ontology highlight
ABSTRACT:
SUBMITTER: de Vink PJ
PROVIDER: S-EPMC6429609 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
de Vink Pim J PJ Andrei Sebastian A SA Higuchi Yusuke Y Ottmann Christian C Milroy Lech-Gustav LG Brunsveld Luc L
Chemical science 20190125 10
A cooperativity framework to describe and interpret small-molecule stabilization of protein-protein interactions (PPI) is presented. The stabilization of PPIs is a versatile and emerging therapeutic strategy to target specific combinations of protein partners within the protein interactome. Currently, the potency of PPI stabilizers is typically expressed by their apparent affinity or EC<sub>50</sub>. Here, we propose that the effect of a PPI stabilizer be best described involving the cooperativi ...[more]