Dataset Information

Efficacy and safety of pemafibrate administration in patients with dyslipidemia: a systematic review and meta-analysis.

ABSTRACT:

Background

Using a meta-analysis of randomized controlled trials (RCTs), this study aimed to investigate the efficacy and safety of pemafibrate, a novel selective peroxisome proliferator-activated receptor ? modulator, in patients with dyslipidemia.

Methods

A search was performed using the MEDLINE, Cochrane Controlled Trials Registry, and ClinicalTrials.gov databases. We decided to employ RCTs to evaluate the effects of pemafibrate on lipid and glucose metabolism-related parameters in patients with dyslipidemia. For statistical analysis, standardized mean difference (SMD) or odds ratio (OR) and 95% confidence intervals (CIs) were calculated using the random effect model.

Results

Our search yielded seven RCTs (with a total of 1623 patients) that satisfied the eligibility criteria of this study; hence, those studies were incorporated into this meta-analysis. The triglyceride concentration significantly decreased in the pemafibrate group (SMD, -?1.38; 95% CI, -?1.63 to -?1.12; P?ConclusionsThe lipid profile significantly improved in the pemafibrate group than in the placebo group. In addition to the pemafibrate group having an improved lipid profile, which was comparable with that of the fenofibrate group, the AEs were significantly lower than in the fenofibrate group and an improvement in hepatobiliary enzyme activity was also recognized. However, we believe that actual clinical data as well as long-term efficacy and safety need to be investigated in the future.

SUBMITTER: Ida S

PROVIDER: S-EPMC6429757 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Publications

Efficacy and safety of pemafibrate administration in patients with dyslipidemia: a systematic review and meta-analysis.

Ida Satoshi S Kaneko Ryutaro R Murata Kazuya K

Cardiovascular diabetology 20190321 1

<h4>Background</h4>Using a meta-analysis of randomized controlled trials (RCTs), this study aimed to investigate the efficacy and safety of pemafibrate, a novel selective peroxisome proliferator-activated receptor α modulator, in patients with dyslipidemia.<h4>Methods</h4>A search was performed using the MEDLINE, Cochrane Controlled Trials Registry, and ClinicalTrials.gov databases. We decided to employ RCTs to evaluate the effects of pemafibrate on lipid and glucose metabolism-related parameter ...[more]

PMID: 30898163

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Dataset Information

Efficacy and safety of pemafibrate administration in patients with dyslipidemia: a systematic review and meta-analysis.

Background

Methods

Results

Publications

Efficacy and safety of pemafibrate administration in patients with dyslipidemia: a systematic review and meta-analysis.

Similar Datasets

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